A research team led by scientists at AIDS Institute and
Department of Microbiology, Li Ka Shing Faculty of Medicine of The University
of Hong Kong (HKU) have invented a universal antibody drug against HIV/AIDS
which is another promising development towards cure for HIV.
Published in The Journal of Clinical Investigation, the team engineered a neutralising antibody, universally effective "not only against all genetically divergent global HIV-1 strains tested but also promoting the elimination of latently infected cells in a humanised mouse model."
AIDS remains an incurable disease. In the world, HIV/AIDS has
resulted in estimated 40 million deaths while 36.9 million people are still
living with the virus. To end the HIV/AIDS pandemic, it is important to
discover either an effective vaccine or a therapeutic cure.
There are, however, two major scientific challenges: the
tremendous HIV-1 diversity and the antiviral drug-unreachable latency.
Since it is extremely difficult to develop an appropriate
immunogen to elicit broadly neutralising antibodies (bnAbs) against genetically
divergent HIV-1 subtypes, developing existing bnAbs as passive immunisation
becomes a useful approach for HIV-1 prophylaxis and immunotherapy.
Previous studies have investigated the potency, breadth and
crystal structure of many bnAbs including their combination both in vitro and
in vivo.
Naturally occurring HIV-1 resistant strains, however, are
readily found against these so-called bnAbs and result in the failure of
durable viral suppression in bnAb-based monotherapy.
To improve HIV-1 neutralisation breadth and potency,
bispecific bnAb, which blocks two essential steps of HIV-1 entry into target
cells, have been engineered and show promising efficacy in animal models.
Before the publication, tandem bi-specific bnAb has not been
previously investigated in vivo against HIV-1 infection.
The accumulated number of HIV-1 infections has more than
doubled from 4,443 diagnostic cases in 2009 to 9,091 in 2017, despite the
timely introduced combination antiretroviral therapy and prevention
interventions in Hong Kong alone.
Currently, the estimated annual cost is over HK$550 million
for antiretroviral drugs alone per year in Hong Kong, not to mention the rising
issues of life-long financial burdens, drug toxicity and resistant viruses.
The newly invented universal antibody drug brings the hope to
fight these issues. With significantly improved breadth and potency, BiIA-SG
will hopefully be the first "Made in Hong Kong" anti-HIV-1 antibody
drug for clinical development.
Source: https://deccanchronicle.com/lifestyle/health-and-wellbeing/080518/has-a-cure-for-hiv-gotten-closer-scientists-discover-new-possibility.html
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ReplyDeleteI was cured of HIV with the used of natural herbs. My name is luci amber and am from US. I love herbs so much. Most times, injection and drugs are just a waste of time. I was cured 8 months ago, i suffered from HIV for 13 yrs but with the help of Dr.Nana herbal medicine, i was cured within few weeks of drinking the herbs he sent to me through courier delivery service. This same doctor also cured my Aunty from herpes, as soon as i heard she had herpes, i quickly refer her to Dr.Nana and she was cured too after drinking his herbs.I have referred more than 15 persons to Dr.Nana and they were all cured from their various illness. Have you taken herbs before?. You have spent so much money on drugs,injections,surgeries etc and yet you have no good result to show for it. Contact Dr. Nana now, he is a herbalist doctor, i assured you of a cure if you drink his natural herbs. Dr.Nana have herbs that cures Hiv, Herpes, diabetics, asthma, hepatitis, HBP, STD, cancer, chronic, etc. Contact Dr Nana through his Email address on: drnanaherbalsolutionhome@gmail.com or WHATSAPP/CALL him on+2347014784614. Please share the good news to other people once you are cured
I was cured of HIV with the used of natural herbs. My name is luci amber and am from US. I love herbs so much. Most times, injection and drugs are just a waste of time. I was cured 8 months ago, i suffered from HIV for 13 yrs but with the help of Dr.Nana herbal medicine, i was cured within few weeks of drinking the herbs he sent to me through courier delivery service. This same doctor also cured my Aunty from herpes, as soon as i heard she had herpes, i quickly refer her to Dr.Nana and she was cured too after drinking his herbs.I have referred more than 15 persons to Dr.Nana and they were all cured from their various illness. Have you taken herbs before?. You have spent so much money on drugs,injections,surgeries etc and yet you have no good result to show for it. Contact Dr. Nana now, he is a herbalist doctor, i assured you of a cure if you drink his natural herbs. Dr.Nana have herbs that cures Hiv, Herpes, diabetics, asthma, hepatitis, HBP, STD, cancer, chronic, etc. Contact Dr Nana through his Email address on: drnanaherbalsolutionhome@gmail.com or WHATSAPP/CALL him on+2347014784614. Please share the good news to other people once you are cured