Oral presentation by Tilahun Ferede Asena on "Modeling Evolution of HIV/AIDS Disease Progression: A Parametric Semi-Markov Model with Interval Censuring"

The introduction of highly active anti-retroviral therapy (HAART) for the treatment of AIDS patients has made significant improvements in patient survival and quality of life during late 1990 (WHO, 2008). Thus, this work focused on estimation of HIV/AIDS Disease progression using parametric Semi-Markov Models and to assess factors affecting HIV/AIDS Disease progression of individuals who are following ART therapy during 2008-2015 with time-dependent covariates in Yirgalim General Hospital, Ethiopia. The findings of this study indicate that HIV/AIDS Disease progression can vary greatly according to patient’s gender, Body Mass Index, and Weight Gain/Loss during the follow-up, Age of the patient and other unknown factors associated. By including time-dependent covariates, we show that these factors had significant differences in HIV/AIDS Disease progression. Finally, these results underscore the need for selecting appropriate waiting time distribution for each transition in order to accurately estimate disease progression. In our study, we found that Parametric Semi-Markov models are a powerful approach for studying chronic diseases and using appropriate waiting times for specific transitions of disease progression.

Poster Presentation by Hoda namdari moghadam on the title: Disseminated rectal tuberculosis in an HIV-seropositive patient: Case report 

The risk of developing tuberculosis (TB) is estimated to be between 16-27 times greater in people living with HIV than among those without HIV infection. The gastrointestinal (GI) tract has been increasingly affected by tuberculosis, especially in immunocompromised patients. Although strict rectal involvement is rare, the GI site mostly affected is the ileocecal region. Thus, tuberculosis should always be considered in the differential diagnosis of peranal and rectal lesions, and more so in patients infected by the HIV virus. Author present the case of a man presenting a long-term history of fever, night sweats, weight loss, bloody diarrhea, fecal incontinence, tenesmus, and rectal pain. HIV serology was positive. The patient stool sample stained by ziehle-nelson method, which disclosed the diagnosis of rectal tuberculosis.


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