A latent HIV reservoir is a group of immune cells in the body that are infected with HIV but are not actively producing new HIV.
HIV medicines reduce the amount of HIV in the body (called the viral load) by preventing the virus from multiplying. Because the HIV-infected cells in a latent reservoir aren’t producing new copies of the virus, HIV medicines have no effect on them.
People with HIV must take a daily combination of HIV medicines (called an HIV regimen) to keep their viral loads low. If someone is not taking HIV medicines when the infected cells of the latent reservoir begin making HIV again, the viral load in the body will start to increase. That’s why it’s important to continue taking HIV medicines every day as prescribed, even when viral load levels are low.
Finding ways to target and destroy latent reservoirs is one of the major challenges facing HIV researchers. New studies are exploring different strategies for clearing out reservoirs, including:
· Using gene therapy (which means manipulating genes to treat or prevent disease) to cut out certain HIV genes and inactivate the virus in HIV-infected immune cells.
· Developing drugs or other methods that reactivate latent HIV reservoirs so that the immune system or new therapies can effectively eliminate them.
· Developing approaches that enhance the immune system’s ability to recognize and clear reactivated latent HIV reservoirs.
To submit abstracts at STD 2018 conference, please visit: https://std-hiv-aids.cmesociety.com/abstract-submission