In 1927, Austrian
psychiatrist Julius Wagner-Jauregg received the Nobel Prize in Medicine for
curing some patients with brain damage from syphilis by infecting them with
malaria (Yale J Biol Med, June, 2013;86(2):245–254). He got
the idea of causing very high fevers to cure syphilis
after he saw a woman apparently cured of schizophrenia when she suffered a very
high fever and terrible rash on her skin caused by erysipelas, an infection
with streptococcal bacteria.
Ten to thirty years
after a person is infected with syphilis,
the spirochete bacteria can invade the brain to damage a person's thought
process, behavior, mood and ability to reason. Wagner-Jauregg was
correct in treating psychiatric disease with biological methods, but because he
was a Nazi, he has not been recognized as a groundbreaker for medical
treatments for mental disease.
Who was Julius Wagner-Jauregg?
Julius Wagner-Jauregg (7 March 1857 – 27 September 1940) was an Austrian physician, who won the Nobel Prize in
Physiology or Medicine in 1927 and is the only
psychiatrist to have done so. His Nobel award was "for his
discovery of the therapeutic value of malaria inoculation in the treatment of dementia
paralytica". Wagner-Jauregg was a scientist whose scientific studies showed that:
• iodine deficiency causes cretinism (lack of growth in childhood),
• giving iodine can cure an enlarged thyroid, and
• giving a patient
malaria could treat the brain damage caused by syphilis.
Scientists later
learned that a prolonged, high fever does not cure non-syphilitic
schizophrenia, even if it can kill the germ that causes syphilis.
The Nobel
Prize-Winning Experiment
In 1917,
Wagner-Jauregg injected blood from a German soldier infected with malaria into
nine of his patients who were suffering from paresis, schizophrenic-like brain
damage caused by syphilis.
After 7-12 days of very high fevers, the patients were given quinine to treat
the malaria and Neosalvarsan to treat syphilis.
One died, two were sent to insane asylums, and six improved dramatically.
However, four of these six later suffered further brain damage, but two
recovered completely (Psychiatrike. 2013;24(3):208-12). Subsequent
studies showed that about 50 percent of patients responded to this fever
treatment and improved enough to be released from insane asylums. Of those
released from the asylum, 50 percent had no recurrence, but about 15 percent
died from complications of malaria (Science. 2013;342(6159):686).
Temperatures above
105.8 F (41 Celsius) for at least six hours can kill the bacterium that causes syphilis.
However, the brain can be permanently damaged by temperatures that high for that
long.
On the Road to a Cure
for Syphilis
Approximately five to
ten percent of all psychiatric admissions before 1945 were due to syphilis
of the brain, which affected predominantly middle-class males to cause
dementia, psychosis, paralysis and death. Paul Ehrlich, another Nobel
Prize winner, discovered Salvarsan to treat syphilis and also used methylene
blue to treat malaria. In the 1950s, derivatives of methylene blue called
phenothiazines were found by the French company Rhone Poulenc to treat mental
disorders. That was followed by chlorpromazine and other drugs to treat
mental disorders.
Prior to Wagner-Jauregg’s reports of treating
schizophrenia from syphilis
with malaria, doctors had no effective treatment for that disease. Giving
patients malaria was just about the only treatment that allowed some insane
asylum patients to return to their normal lives (Am J Psychiatry.
1946;02:577-582). It allowed psychiatry to become an accepted medical
specialty because it showed that schizophrenia at last had a treatable cause,
killing the bacterium that causes syphilis.
In 1928, Alexander
Fleming noted that mold could prevent the bacterium Staphylococcus from growing
in a petri dish. In 1939, Howard Florey and Ernst Chain extracted and purified
penicillin and all three were awarded the Nobel Prize in Medicine. Today all
cases of syphilis
can be cured as long as an infected person is diagnosed and treated properly
and early enough.
Syphilis Symptoms
Syphilis
is transmitted during vaginal, anal or oral sex with an infected person.
An unborn child can get it from an infected mother. You do not get
syphilis from doorknobs, toilet seats, swimming pools, clothing, bathtubs, or
silverware.
Primary Syphilis: From 10 to 90 days
after sex with an infected partner, a person usually develops a painless single
skin ulcer called a chancre in the genitals, anus or mouth. It usually
goes away after a week or two with no treatment whatever. Many infected
people develop no chancre at all and have no other symptoms.
Secondary
Syphilis: Two to eight weeks after being infected, a person may develop a
non-itchy rash, usually reddish-brown spots on the bottoms of the feet and on
the palms of the hands. Other symptoms can include a sore throat, fever,
swollen lymph glands, headaches, fatigue, muscle aches, warts on the genitals,
loss of appetite and joint pain. If you are treated properly with antibiotics,
you should be cured. However, if you do not receive treatment, you can
suffer tertiary syphilis with permanent incurable damage.
Tertiary Syphilis: Ten, twenty or
more years later, the bacterium can grow in and destroy any part of the body.
It can cause blindness, dementia, schizophrenia, paralysis, loss of feeling,
arthritis, ruptured blood vessels and liver damage.
Source: http://www.drmirkin.com/histories-and-mysteries/julius-wagnerjaureggs-nobel-prize-for-syphilis-treatment.html
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